120 research outputs found

    Population Dynamics of Long-tailed Ducks Breeding on the Yukon-Kuskokwim Delta, Alaska

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    Population estimates for long-tailed ducks in North America have declined by nearly 50% over the past 30 years. Life history and population dynamics of this species are difficult to ascertain, because the birds nest at low densities across a broad range of habitat types. Between 1991 and 2004, we collected information on productivity and survival of long-tailed ducks at three locations on the Yukon-Kuskokwim Delta. Clutch size averaged 7.1 eggs, and nesting success averaged 30%. Duckling survival to 30 days old averaged 10% but was highly variable among years, ranging from 0% to 25%. Apparent annual survival of adult females based on mark-recapture of nesting females was estimated at 74%. We combined these estimates of survival and productivity into a matrix-based population model, which predicted an annual population decline of 19%. Elasticities indicated that population growth rate (?) was most sensitive to changes in adult female survival. Further, the relatively high sensitivity of ? to duckling survival suggests that low duckling survival may be a bottleneck to productivity in some years. These data represent the first attempt to synthesize a population model for this species. Although our analyses were hampered by the small sample sizes inherent in studying a dispersed nesting species, our model provides a basis for management actions and can be enhanced as additional data become available.Les estimations de populations d’hareldes kakawis en AmĂ©rique du Nord ont chutĂ© de prĂšs de 50 pour cent ces 30 derniĂšres annĂ©es. Le cycle biologique et la dynamique des populations de cette espĂšce sont difficiles Ă  Ă©tablir car ces oiseaux nichent moyennant de faibles densitĂ©s dans une vaste gamme d’habitats. De 1991 Ă  2004, nous avons recueilli des donnĂ©es sur la productivitĂ© et la survie des hareldes kakawis Ă  trois emplacements du delta Yukon-Kuskokwim. Les couvĂ©es atteignaient 7,1 oeufs en moyenne, tandis que le succĂšs de reproduction s’établissait gĂ©nĂ©ralement Ă  30 pour cent. En moyenne, 10 pour cent des jeunes canards survivaient jusqu’à l’ñge de 30 jours, mais ce taux variait beaucoup d’une annĂ©e Ă  l’autre, allant de 0 pour cent Ă  25 pour cent. Annuellement, d’aprĂšs la mĂ©thode par marquage et recapture des femelles nidificatrices, la survie apparente des femelles adultes Ă©tait Ă©valuĂ©e Ă  74 pour cent. Nous avons combinĂ© ces estimations de survie et de productivitĂ© dans un modĂšle de population matriciel, ce qui a permis de prĂ©dire un dĂ©clin de population annuel de 19 pour cent. Selon les Ă©lasticitĂ©s, le taux de croissance de la population (?) Ă©tait plus sensible aux changements dans le cas de la survie des femelles adultes. Par ailleurs, la sensibilitĂ© relativement Ă©levĂ©e du ? par rapport Ă  la survie des jeunes canards laisse croire que le faible taux de survie des jeunes canards pourrait prĂ©senter une embĂ»che en matiĂšre de productivitĂ© d’ici quelques annĂ©es. Ces donnĂ©es reprĂ©sentent la premiĂšre tentative de synthĂšse d’un modĂšle de population pour cette espĂšce. Bien que nos analyses aient Ă©tĂ© gĂȘnĂ©es par la petite taille des Ă©chantillons inhĂ©rente Ă  l’étude d’espĂšces de nidification dispersĂ©es, notre modĂšle fournit un fondement permettant d’aboutir Ă  des mesures de gestion en plus de prĂ©senter la possibilitĂ© d’ĂȘtre amĂ©liorĂ© au fur et Ă  mesure que des donnĂ©es supplĂ©mentaires sont disponibles

    Seasonal Movements and Distribution of Steller’s Eiders (Polysticta stelleri) Wintering at Kodiak Island, Alaska

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    We used satellite telemetry in 2004–06 to describe the annual movements and habitat use of a segment of the Pacific population of Steller’s Eiders (Polysticta stelleri) that winters at Kodiak Island, Alaska. Information about broad-scale patterns of seasonal distribution and links among annual cycle stages is critical for interpreting population trends and developing conservation strategies. We captured birds in Chiniak Bay at Kodiak Island in late February and early March and monitored the movements after departure from Kodiak Island of 24 satellite-tagged birds: 16 after-second-year (ASY) age class females, one second-year age class female, and seven ASY males. All birds used the same intercontinental migration corridor during spring, but routes and chronology of spring migration appeared to vary by year and among individuals. Sixteen of the 24 birds that were tracked migrated to breeding areas along the Arctic coast of Russia from the Chukotka Peninsula to the Taymyr Peninsula; five birds, assumed to be non-breeding, spent the summer in nearshore waters of Russia and Alaska; and the remaining three birds either died during spring migration or had failed transmitters. Thirteen birds were tracked to molt sites that were broadly distributed along the coast of Alaska. Molt sites included St. Lawrence Island, the Kuskokwim Shoals, Kamishak Bay, and three sites along the Alaska Peninsula. Twelve of these 13 birds returned to Kodiak Island to winter, and a single male wintered on the Alaska Peninsula. Steller’s Eiders marked during winter at Kodiak Island were widely distributed during the breeding season, but a large proportion of marked birds returned to molting and wintering areas in two years of the study.De 2004 Ă  2006, nous avons recouru Ă  la tĂ©lĂ©mĂ©trie satellitaire pour dĂ©crire l’utilisation de l’habitat et les mouvements annuels d’un segment de la population d’eiders de Steller (Polysticta stelleri) dans la rĂ©gion du Pacifique, eiders qui hivernent sur l’üle Kodiak, en Alaska. Il est essentiel d’obtenir des donnĂ©es sur les tendances Ă  grande Ă©chelle de la rĂ©partition saisonniĂšre et des liens entre les divers stades du cycle annuel de ces oiseaux afin d’ĂȘtre en mesure d’interprĂ©ter leurs tendances dĂ©mographiques et d’élaborer des stratĂ©gies de conservation. Nous avons capturĂ© des oiseaux dans la baie Chiniak de l’üle Kodiak vers la fin fĂ©vrier et le dĂ©but mars. AprĂšs notre dĂ©part de l’üle Kodiak, nous avons surveillĂ© les mouvements de 24 oiseaux pistĂ©s par satellite : 16 femelles de plus de deux ans, une femelle de deux ans et sept mĂąles de plus de deux ans. Tous les oiseaux ont empruntĂ© le mĂȘme couloir de migration intercontinental au printemps, mais les routes et la chronologie de la migration printaniĂšre semblaient varier d’une annĂ©e Ă  l’autre et d’un individu Ă  l’autre. Seize des24 oiseaux pistĂ©s ont migrĂ© vers des aires de reproduction situĂ©es le long de la cĂŽte arctique de la Russie, depuis la presqu’üle de Tchoukotkae jusqu’à la presqu’üle de TaĂŻmyr; cinq oiseaux, probablement non reproducteurs, ont passĂ© l’étĂ© dans les eaux cĂŽtiĂšres de la Russie et de l’Alaska, tandis que les trois autres oiseaux sont morts pendant la migration printaniĂšre ou Ă©taient dotĂ©s de transmetteurs dĂ©fectueux. Treize oiseaux ont Ă©tĂ© repĂ©rĂ©s Ă  des sites de mue largement rĂ©partis le long de la cĂŽte de l’Alaska. Parmi ces sites, notons ceux de l’üle Saint-Laurent, du haut-fond de Kuskokwim, de la baie de Kamishak et de trois autres sites le long de la pĂ©ninsule de l’Alaska. Douze de ces 13 oiseaux sont retournĂ©s Ă  l’üle Kodiak pour passer l’hiver, et un seul mĂąle a hivernĂ© dans la pĂ©ninsule de l’Alaska. Les eiders de Steller qui ont Ă©tĂ© marquĂ©s Ă  l’üle Kodiak pendant l’hiver Ă©taient largement rĂ©partis pendant la saison de reproduction, mais une grande proportion d’oiseaux pistĂ©s sont retournĂ©s aux aires de mue et d’hivernage au cours des deux annĂ©es visĂ©es par l’étude

    Relevance similarity: an alternative means to monitor information retrieval systems

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    BACKGROUND: Relevance assessment is a major problem in the evaluation of information retrieval systems. The work presented here introduces a new parameter, "Relevance Similarity", for the measurement of the variation of relevance assessment. In a situation where individual assessment can be compared with a gold standard, this parameter is used to study the effect of such variation on the performance of a medical information retrieval system. In such a setting, Relevance Similarity is the ratio of assessors who rank a given document same as the gold standard over the total number of assessors in the group. METHODS: The study was carried out on a collection of Critically Appraised Topics (CATs). Twelve volunteers were divided into two groups of people according to their domain knowledge. They assessed the relevance of retrieved topics obtained by querying a meta-search engine with ten keywords related to medical science. Their assessments were compared to the gold standard assessment, and Relevance Similarities were calculated as the ratio of positive concordance with the gold standard for each topic. RESULTS: The similarity comparison among groups showed that a higher degree of agreements exists among evaluators with more subject knowledge. The performance of the retrieval system was not significantly different as a result of the variations in relevance assessment in this particular query set. CONCLUSION: In assessment situations where evaluators can be compared to a gold standard, Relevance Similarity provides an alternative evaluation technique to the commonly used kappa scores, which may give paradoxically low scores in highly biased situations such as document repositories containing large quantities of relevant data

    Improving a gold standard: treating human relevance judgments of MEDLINE document pairs

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    Given prior human judgments of the condition of an object it is possible to use these judgments to make a maximal likelihood estimate of what future human judgments of the condition of that object will be. However, if one has a reasonably large collection of similar objects and the prior human judgments of a number of judges regarding the condition of each object in the collection, then it is possible to make predictions of future human judgments for the whole collection that are superior to the simple maximal likelihood estimate for each object in isolation. This is possible because the multiple judgments over the collection allow an analysis to determine the relative value of a judge as compared with the other judges in the group and this value can be used to augment or diminish a particular judge’s influence in predicting future judgments. Here we study and compare five different methods for making such improved predictions and show that each is superior to simple maximal likelihood estimates

    Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB)

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    BACKGROUND:Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. CL causes enormous suffering in many countries worldwide. There is no licensed vaccine against CL, and the chemotherapy options show limited efficacy and high toxicity. Localization of the parasites inside host cells is a barrier to most standard chemo- and immune-based interventions. Hence, novel drugs, which are safe, effective and readily accessible to third-world countries and/or drug delivery technologies for effective CL treatments are desperately needed. METHODOLOGY/PRINCIPAL FINDINGS:Here we evaluated the antileishmanial properties and delivery potential of polyhexamethylene biguanide (PHMB; polyhexanide), a widely used antimicrobial and wound antiseptic, in the Leishmania model. PHMB showed an inherent antileishmanial activity at submicromolar concentrations. Our data revealed that PHMB kills Leishmania major (L. major) via a dual mechanism involving disruption of membrane integrity and selective chromosome condensation and damage. PHMB's DNA binding and host cell entry properties were further exploited to improve the delivery and immunomodulatory activities of unmethylated cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN). PHMB spontaneously bound CpG ODN, forming stable nanopolyplexes that enhanced uptake of CpG ODN, potentiated antimicrobial killing and reduced host cell toxicity of PHMB. CONCLUSIONS:Given its low cost and long history of safe topical use, PHMB holds promise as a drug for CL therapy and delivery vehicle for nucleic acid immunomodulators
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